Deep neural networks perform well for image recognition, speech recognition, and pattern analysis. This type of neural network has also been used in the medical field, where it has displayed good performance in predicting or classifying patient diagnoses. An example is the U-Net model, which has demonstrated good performance in data segmentation, an important technology in the field of medical imaging. However, deep neural networks are vulnerable to adversarial examples. Adversarial examples

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... samples created by adding a small amount of noise to an original data sample in such a way that to human perception they appear to be normal data but they will be incorrectly classified by the classification model. Adversarial examples pose a significant threat in the medical field, as they can cause models to misidentify or misclassify patient diagnoses. In this paper, I propose an advanced adversarial training method to defend against such adversarial examples. An advantage of the proposed method is that it creates a wide variety of adversarial examples for use in training, which are generated by the fast gradient sign method (FGSM) for a range of epsilon values. A U-Net model trained on these diverse adversarial examples will be more robust to unknown adversarial examples. Experiments were conducted using the ISBI 2012 dataset, with TensorFlow as the machine learning library. According to the experimental results, the proposed method builds a model that demonstrates segmentation robustness against adversarial examples by reducing the pixel error between the original labels and the adversarial examples to an average of 1.45.