1918 Archives of Internal Medicine  
A study of the effect of organisms on rabbits' appendixes when intravenously injected showed that this organ in these animals was not always the tissue most seriously attacked, and, furthermore, was never the only organ to exhibit alterations in its structure. The injection of large doses of active cultures produced a widely disseminated infection, with the development of lesions in several different organs. Although the material was selected with a view to demonstrate an elective affinity on
more » ... e part of the organisms for the appendix, we were unable to determine such an affinity, even though the appendix was affected in a large number of animals. The striking feature of the experiments was the almost uniform regularity with which certain organs were attacked. Lesions were found more frequently in the stomach, lungs, skin and endocardium than in the appendix. The entire gastro-intestinal tract was commonly the seat of hemorrhages and presented this picture in the following order : stomach, appendix, duodenum, small intestine, cecum and large bowel. Hemorrhages were also noted in the thymus, muscle, pericardium, pleura, and periarticular tissues and eye, in the order named. Almost without exception the spleen was enlarged, with tense capsule and a soft, deepl y\x=req-\ colored pulp. Vegetative endocarditis was found in thirteen rabbits. Where there was no hemorrhage, acute lesions were found at times in the myocardium, liver, kidney and skeletal muscles. Sometimes these areas could be recognized in the gross as small yellowish foci. The joint fluid of the knees was frequently cloudy, or the synovial lining quite pink, and the organisms were recovered from these in forty-eight rabbits. Cultures made from the brain in forty-six rabbits gave eight positive results. Twenty-one of these animals showed small petechiae in the lining of the lateral ventricles, and five of the animals showed small hemorrhages in the white matter of the cord. Ten positive cultures were obtained from the gall-bladder. From this brief descrip¬ tion it is evident that the injection of micro-organisms into rabbits' veins produced a widespread infection, and in this article we wish to discuss in detail the lesions observed.
doi:10.1001/archinte.1918.00090160066007 fatcat:f5c6tp624bg2pjxlcvdnx2rmwe