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Synaptic processes and immune-related pathways implicated in Tourette Syndrome [article]

Fotis Tsetsos, Dongmei Yu, Jae Hoon Sul, Alden Y Huang, Cornelia Illmann, Lisa Osiecki, Sabrina Darrow, Matthew E Hirschtritt, Erica Greenberg, Kirsten R Muller-Vahl, Manfred Stuhrmann, Yves Dion (+56 others)
2020 biorxiv/medrxiv   pre-print

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Tourette Syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with Tourette Syndrome (TS) and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal
more » ... glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating Ligand-gated Ion Channel Signaling, Lymphocytic, and Cell Adhesion and Transsynaptic Signaling processes. MAGMA analysis further supported the involvement of the Cell Adhesion and Trans-synaptic Signaling gene set. The Lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of Ligand-gated Ion Channel Signaling reinforce the role of GABA in TS, while the association of Cell Adhesion and Transsynaptic Signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders.
doi:10.1101/2020.04.24.20047845 fatcat:tntyevemwjgoziyunenlxzyhwq
Citation

Fotis Tsetsos, Dongmei Yu, Jae Hoon Sul, Alden Y Huang, Cornelia Illmann, Lisa Osiecki, Sabrina Darrow, Matthew E Hirschtritt, Erica Greenberg, Kirsten R Muller-Vahl, Manfred Stuhrmann, Yves Dion, Guy Rouleau, Harald Aschauer, Mara Stamenkovic, Monika Schlögelhofer, Paul Sandor, Cathy L Barr, Marco Grados, Harvey S Singer, Markus M Nöthen, Johannes Hebebrand, Anke Hinney, Robert A King, Thomas V Fernandez, Csaba Barta, Zsanett Tarnok, Peter Nagy, Christel Depienne, Yulia Worbe, Andreas Hartmann, Cathy L Budman, Renata Rizzo, Gholson J Lyon, William M McMahon, James R Batterson, Danielle C Cath, Irene A Malaty, Michael S Okun, Cheston Berlin, Douglas W Woods, Paul C Lee, Joseph Jankovic, Mary M Robertson, Donald L Gilbert, Lawrence W Brown, Barbara J Coffey, Andrea Dietrich, Pieter J Hoekstra, Samuel Kuperman, Samuel Zinner, Michael Wagner, James A Knowles, A Jeremy Willsey, Jay A Tischfield, Gary A Heiman, Nancy J Cox, Nelson B Freimer, Benjamin Neale, Lea K Davis, Giovanni Coppola, Carol A Mathews, Jeremiah M Scharf, Peristera Paschou, the Tourette Association of America International Consortium for Genetics, the Gilles de la Tourette GWAS Replication Initiative, the Tourette International Collaborative Genetics Study, the Psychiatric Genomics Consortium Tourette Syndrome Working Group. "Synaptic processes and immune-related pathways implicated in Tourette Syndrome." biorxiv/medrxiv (2020)