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Original Paper Effect of VEGFR, PDGFR and PI3K/mTOR Targeting in Glioblastoma
2015
Current Health Sciences Journal
unpublished
Resistance to targeted therapy is a well known obstacle in cancer therapy. The cross-talk between several growth factor receptors generates redundancy in their intracellular pathways that usually mediates resistance to receptor targeted therapy. Simultaneous inactivation of two or more growth factor receptors has been suggested to prevent the cross-talk between their signaling pathways and to better eliminate malignant cells. Here we found that targeted therapy against these receptors induced
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