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The simplicity and cost-effectiveness of CRISPR technology have made high-throughput pooled screening approaches accessible to virtually any laboratory. Analyzing the large sequencing data derived from these studies, however, still demands considerable bioinformatics expertise. Various methods have been developed to lessen this requirement, but there are still three tasks for accurate CRISPR screen analysis that involve bioinformatic know-how, if not prowess: designing a proper statisticaldoi:10.1101/gr.245571.118 pmid:31015259 pmcid:PMC6581060 fatcat:crd7iinc7bg3pfyewua6ew7d6a