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Distinct roles of nitric oxide synthases and interstitial cells of Cajal in rectoanal relaxation
2005
American Journal of Physiology - Gastrointestinal and Liver Physiology
Terauchi, Akiko, Daisuke Kobayashi, and Hiroshi Mashimo. Distinct roles of nitric oxide synthases and interstitial cells of cajal in rectoanal relaxation. Nitric oxide (NO) relaxes the internal anal sphincter (IAS), but its enzymatic source(s) remains unknown; neuronal (nNOS) and endothelial (eNOS) NO synthase (NOS) isoforms could be involved. Also, interstitial cells of Cajal (ICC) may be involved in IAS relaxation. We studied the relative roles of nNOS, eNOS, and c-Kit-expressing ICC for IAS
doi:10.1152/ajpgi.00005.2005
pmid:15845873
fatcat:s3hcnkdrgfenpfhu4simaqxuju