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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a PAR1- and PAR4-dependent mechanism
2018
Proceedings for Annual Meeting of The Japanese Pharmacological Society
and purpose-Thrombin is massively released upon tissue damage associated with bleeding or chronic inflammation. The question of the effects of such thrombin on tissue regrowth and repair has been scarcely addressed, and only in cancer cell lines. The purpose of the present study was to determine thrombin's pharmacological effects on human intestinal epithelium growth, proliferation and apoptosis, using 3-dimentional cultures of human colon organoids. Experimental design-Crypts were isolated
doi:10.1254/jpssuppl.wcp2018.0_or21-2
fatcat:isacpev7n5fwxk4bn3vkhiurgq