In Vitro Transformation of Chicken Bone Marrow Cells with Avian Erythroblastosis Virus

Thomas Graf
1975 Zeitschrift für Naturforschung C - A Journal of Biosciences  
An in vitro transformation of bone marrow cells has been demonstrated for two strains of avian erythroblastosis virus (AEV-R and AEV-ES4). The transformed cells were indistinguishable from in vivo transformed erythroblasts in morphology and staining characteristics and could be propagated to large numbers. The transformation efficiency could be greatly increased by the addition of dimethyl-sulfoxide (DMSO). The number of foci appearing in the presence of DMSO was proportional to the virus
more » ... to the virus concentration.
doi:10.1515/znc-1975-11-1232 fatcat:rnacysix2nhc5hlsjpebqtzouq