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Synergistic Effects of Growth Factors on the Regulation of Smooth Muscle Cell Scavenger Receptor Activity
1995
Journal of Biological Chemistry
Rabbit smooth muscle cells (SMC) express types I and II scavenger receptors (ScR) that are up-regulated by platelet secretion products. In the current studies we investigated the effect of growth factors secreted by platelets on ScR activity in rabbit and human SMC. Platelet-derived growth factor (PDGF BB) and transforming growth factor  1 (TGF- 1 ) at 10 ng/ml increased ScR activity in rabbit SMC (by approximately 4-and 2-fold, respectively) but not in human SMC. Epidermal growth factor
doi:10.1074/jbc.270.37.21672
pmid:7665582
fatcat:jvcrcyn7pjetddrdwjd7pxhame