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Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis
American Journal of Physiology - Gastrointestinal and Liver Physiology
Inhibition of poly(ADPribose) polymerase attenuates inflammation in a model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 279: G641-G651, 2000.-Crohn's disease is a chronic disease characterized by oxidant-induced tissue injury and increased intestinal permeability. A consequence of oxidative damage is the accumulation of DNA strand breaks and activation of poly(ADP-ribose) polymerase (PARP), which subsequently catalyzes ADP-ribosylation of target proteins. In this study, wedoi:10.1152/ajpgi.2000.279.3.g641 pmid:10960365 fatcat:wv4uz2wbf5dgrjnd2ilaqhxrhm