Concentrations of selenium in whole blood, plasma, and leucocytes were determined in 16 patients with coeliac disease confirmed by biopsy and 32 controls. All the patients were clinically well and receiving gluten free diets. The concentrations of selenium were significantly lower in the leucocytes, blood, and plasma of patients compared with controls, probably indicating a decrease in the body content of selenium. A high incidence of malignancy in coeliac disease has been reported. As a

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... ive role for selenium against cancer has been postulated, the importance of this unexpected observation of lowered tissue concentrations of selenium requires further investigation. S09 4XY LESLEY J HINKS, FIMLS, senior medi-al laboratory scientific officer KAREN D INWARDS, fourth year medical student BARBARA LLOYD, FIMLS, senior chief medical laboratory scientific officer BARBARA E CLAYTON, FRCP, FRCPATH, professor of chemical pathology and human metabolism