The IgA system: a comparison of structure and function in different species

Veerle Snoeck, Iain R. Peters, Eric Cox
2006 Veterinary Research  
To cite this version: Veerle Snoeck, Iain Peters, Eric Cox. The IgA system: a comparison of structure and function in different species. Abstract -The predominant immunoglobulin isotype on most mucosal surfaces is secretory immunoglobulin A (SIgA), a polypeptide complex comprising two IgA monomers, the connecting J chain, and the secretory component. The molecular stability and strong anti-inflammatory properties make SIgA particularly well suited to provide protective immunity to the
more » ... ty to the vulnerable mucosal surfaces by preventing invasion of inhaled and ingested pathogens. In contrast to SIgA, IgA in serum functions as an inflammatory antibody through interaction with FcαR on immune effector cells. Although IgA appears to share common features and protective functions in different species, significant variations exist within the IgA systems of different species. This review will give an overview of the basic concepts underlying mucosal IgA defence which will focus on the variations present among species in structure, antibody repertoire development, pIgR-mediated transport, colostral IgA content, hepatobiliary transport, and function with particular emphasis on the IgA system of the pig and dog. These interspecies variations emphasise the importance of elucidating and analysing the IgA system within the immune system of the species of interest rather than inferring roles from conclusions made in human and mouse studies. IgA / polymeric IgR / FcαR / mucosal antibodies / domestic animals
doi:10.1051/vetres:2006010 pmid:16611558 fatcat:zr3ipsr2dzcnza7o45h7j44tvi