Objective Adherence to ARV medications has been shown to improve treatment outcomes in HIV positive patients. Given that treatment to ARV is lifelong, adherence has become a critical issue as it may reduce over time. Measuring adherence is therefore imperative in programming. There are different methods of measuring adherence with advantages and disadvantages depending on the context and the time. This study therefore compares two adherence measurement scales; Medication Possession Ration (MPR)

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... and self-report adherence in Cameroon.Results The self-report adherence was 82.9% while adherence from the MPR was 73.4%. The two measures were compared using kappa statistics. There was substantial agreement between the two scales of 66% (p=0.54). The results of both self-report adherence and MPR were also compared with viral load suppression and the difference between viral load suppression and MPR was significant (p<0.01). The difference in adherence between viral load suppression and the self-report measure was also shown to be significant (p<0.01).