Impaired Awareness of Hypoglycemia Disrupts Blood Flow to Brain Regions Involved in Arousal and Decision Making in Type 1 Diabetes

Munachiso Nwokolo, Stephanie A. Amiel, Owen O'Daly, Megan L. Byrne, Bula M. Wilson, Andrew Pernet, Sally M. Cordon, Ian A. Macdonald, Fernando O. Zelaya, Pratik Choudhary
2019 Diabetes Care  
Impaired awareness of hypoglycemia (IAH) affects one-quarter of adults with type 1 diabetes and significantly increases the risk of severe hypoglycemia. Differences in regional brain responses to hypoglycemia may contribute to the susceptibility of this group to problematic hypoglycemia. This study investigated brain responses to hypoglycemia in hypoglycemia aware (HA) and IAH adults with type 1 diabetes, using three-dimensional pseudo-continuous arterial spin labeling (3D pCASL) functional MRI
more » ... to measure changes in regional cerebral blood flow (CBF).
doi:10.2337/dc19-0337 pmid:31455689 fatcat:ehnut2zjrvfszhh5vlvpft5g7q