Biochemical association between essential trace elements and susceptibility to Leishmania major in BALB/c and C57BL/6 mice

Marzyeh Amini, Hossein Nahrevanian, Shohreh Khatami, Mahin Farahmand, Fatemeh Mirkhani, Seifoddin Javadian
2009 Brazilian Journal of Infectious Diseases  
Several enzymes that contribute to immune system responses require zinc and copper as trace elements for their activity. We examined zinc and copper levels in two susceptible Balb/c mouse lines and resistant C57bl/6 mice infected with Leishmania major MRHO/IR/75/ER, a prevalent strain that causes cutaneous leishmaniasis in Iran. Serum Zn and Cu were determined by flame atomic absorption spectrophotometry. Higher Cu levels were found in infected C57bl/6 mice and higher Zn levels were found in
more » ... ected Balb/c mice. Also, Cu/Zn ratios were increased in both the Balb/c and the C57bl/6 mice. We conclude that concentrations of essential trace elements vary during cutaneous leishmaniasis infection and that this variation is associated with susceptibility/resistance to Leishmania major in Balb/c and C57bl/6 mice. We detected Zn deficiency in the plasma of infected Balb/c mice; possibly, therapeutic administration of Zn would be useful for treating this form of leishmaniasis. Increases in Cu level might increase resistance to leishmaniasis. Based on our findings, the Cu/Zn ratio could be a useful marker for the pathophysiology of leishmaniasis.
doi:10.1590/s1413-86702009000200002 pmid:20140348 fatcat:7dlplwn7uzfr7ctxhc3v32lfxu