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Tissue factor (TF)/VIIa/protease-activated receptor 2 (PAR2) has been shown to trigger the ERK1/2 signaling pathway. This was shown to be closely associated with the proliferation and migration of SW620 colon cancer cells; however, the detailed mechanisms remain unclear. The aim of the present study was to elucidate the effects of calcium signaling on the proliferation and migration of SW620 cells induced by coagulation factor VIIa. The results demonstrated that VIIa and PAR2 agonist PAR2-APdoi:10.3892/mmr.2014.2665 pmid:25323578 fatcat:ngu6dld5bzf67en5ht4z6smiga