Research objective. To carry out the overview of the published works devoted to assessment of efficiency and safety of the phytodrug mastodynon, which includes Vitexagnus-castus extract, in treatment of mastalgia caused by a benign dysplasia of mammary glands and/or a premenstrual syndrome, with the analysis of use of the obtained data in clinical practice of obstetrician-gynecologist. Materials and methods. The foreign and domestic articles which are selected in Pubmed, eLIBRARY according to

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... ywords «cyclic mastalgia», «diffusion benign dysplasia of mammary glands», «premenstrual syndrome», «hyperprolactinemia», «Vitexagnus-castus», «mastodynon» are used. The results of the analysed clinical trials demonstrate efficiency of phytodrugs in treatment of mastalgia in patients with various forms of diffusion mastopathy and premenstrual syndrome.Conclusion. Mastodynon can be recommended as effective and safe first-choice drug for treatment of a cyclic mastalgia in patients with a diffusion benign dysplasia of mammary glands and a premenstrual syndrome.