Research Models for Studying Vascular Calcification

Jaqueline Herrmann, Milen Babic, Markus Tölle, Markus van der Giet, Mirjam Schuchardt
2020 International Journal of Molecular Sciences  
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process. The exact underlying mechanisms are not fully elucidated and reliable treatment options are lacking. Due to the complex pathophysiology, various research models exist evaluating different aspects of VC. This review aims to give an overview of the cell and animal
more » ... used so far to study the molecular processes of VC. Here, in vitro cell culture models of different origins, ex vivo settings using aortic tissue and various in vivo disease-induced animal models are summarized. They reflect different aspects and depict the (patho)physiologic mechanisms within the VC process.
doi:10.3390/ijms21062204 pmid:32210002 fatcat:5jjavoft5navlomz5asvdurxbe