The present study investigated the association between the severity of depressive mood and nocturia in young Asian adult men. Participants were 3,127 adult male Facebook users aged 20–40 years who could read and write traditional Chinese. Participants completed an online questionnaire about their demographic characteristics, the frequency of getting up to urinate during the night (International Prostate Symptoms Score [IPSS]), and the frequency of experiencing depressive symptoms (Taiwanese

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... ession Questionnaire [TDQ]). The severity of lower urinary tract symptoms (LUTS) and those who had nocturia were classified using the IPSS. Student's t test and Pearson's chi square test were used to compare participants with and without nocturia. Univariate and multivariate logistic regression were used to evaluate the predictive factors for nocturia. Two hundred fifty-one (8.0%) participants had nocturia, and 21.9% were suspected to have depression. Age over 30 years, body mass index over 25 kg/m2, the presence of moderate/severe LUTS, and higher TDQ scores were predictive of nocturia. Depression was associated with nocturia in young Asian adult males. Young men with nocturia who are at risk of developing depression should be identified with a culturally relevant questionnaire. Early referral for psychiatric assessment and intervention may be warranted.