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Impact of High-Sensitivity Troponin I Testing with Sex-Specific Cutoffs on the Diagnosis of Acute Myocardial Infarction

C. Trambas, J. W. Pickering, M. Than, C. Bain, L. Nie, E. Paul, A. Dart, A. Broughton, H. G. Schneider
2016 Clinical Chemistry  

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BACKGROUND: High-sensitivity cardiac troponin I (hs-cTnI) assays show sex-dependent differences in the 99th percentile of healthy populations, with concentrations in women approximately 50% lower. The adoption of sex-specific cutoffs seems appropriate, although it is not yet clear what effect these will have on acute myocardial infarction (AMI) diagnosis and management. METHODS: We conducted a retrospective pre-and postchangeover analysis of troponin I testing in the 6 months before and after
more » ... ving from the contemporary Abbott Architect TnI assay (cTnI) to hs-cTnI at 2 tertiary centers in Australia and New Zealand. The cTnI cutoff was 30 ng/L for both sexes, whereas a female-specific cutoff of 16 ng/L was adopted upon changeover to hsTnI.
doi:10.1373/clinchem.2015.252569 pmid:27117468 fatcat:ntnb5lcicfcxnamctzwnrzhr5e
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C. Trambas, J. W. Pickering, M. Than, C. Bain, L. Nie, E. Paul, A. Dart, A. Broughton, H. G. Schneider. "Impact of High-Sensitivity Troponin I Testing with Sex-Specific Cutoffs on the Diagnosis of Acute Myocardial Infarction." Clinical Chemistry 62.6 (2016) 831-838