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Etv5 is not required for Schwann cell development but is required to regulate the Schwann cell response to peripheral nerve injury
[article]
2020
bioRxiv
pre-print
Schwann cells are the principal glial cells of the peripheral nervous system, and their development into myelinating glia is critically dependent on MEK/ERK signaling. Ets-domain transcription factors (Etv1, Etv4, Etv5) are common downstream effectors of MEK/ERK signalling, but so far, only Etv1 has been ascribed a role in Schwann cell development, and only in non-myelinating cells. Here, we examined the role of Etv5, which is expressed in Schwann cell precursors, including neural crest cells
doi:10.1101/2020.09.23.309815
fatcat:chkiu6flcvcwlims27qj5kux5i