With the increasing needs of accurate simulation, the 3-D diffusion reactor physics module has been implemented in HTGR's engineering simulator to give better neutron dynamics results instead of point kinetics model used in previous nuclear power plant simulators. As the requirement of real-time calculation of nuclear power plant simulator, the cross-sections used in 3-D diffusion module must be calculated very efficiently. Normally, each cross-section in simulator is calculated in the form of

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... olynomial by function of several concerned variables, the expression of which was finalized by multivariate regression from large number scattered database generated by previous calculation. Since the polynomial is explicit and prepared in advance, the cross-sections could be calculated quickly enough in running simulator and achieve acceptable accuracy especially in LWR simulations. However, some of concerned variables in HTGR are in large scope and also the relationships of these variables are non-linear and very complex, it is very hard to use polynomial to meet full range accuracy. In this paper, a cross-section generating method used in HTGR simulator is proposed, which is based on machine learning methods, especially deep neuron network and tree regression methods. This method first uses deep neuron networks to consider the nonlinear relationships between different variables and then uses a tree regression to achieve accurate cross-section results in full range, the parameters of deep neuron networks and tree regression are learned automatically from the scattered database generated by VSOP. With the numerical tests, the proposed cross-section generating method could get more accurate cross-section results and the calculation time is acceptable by the simulator.