Irisin is a new myokine that is suspected to influence metabolic syndrome (MetS). However, there is a great controversy as regard its level in cases of MetS and its correlation with different metabolic parameters. The aim of the present study was to assess irisin levels in MetS patients and study its relationship to metabolic and liver functions to evaluate the possible role of the liver in regulation of this level. 60 subjects included in this experiment and divided into three groups: Group I

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... normal control persons), group II (MetS patients with normal liver enzymes) and group III (MetS with elevated liver enzymes and fatty liver). Serum irisin levels showed significant increases in group II and III compared with group I and significant increases in group III compared with group II. Also, irisin levels were positively correlated with body mass index, serum triglycerides, homeostatic model assessment of insulin resistance index (HOMA-IR), and liver enzymes. We concluded that serum irisin level increased in patients with MetS especially those with elevated liver enzymes and had a positive correlation with parameters of lipid metabolism and glucose homeostasis with the possibility of hepatic clearance to irisin.