Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia that leads to oxidative stress. Antioxidant agents can be used to reduce oxidative stress. Olae (Etlingera calophrys) is one of the plants that exhibit antioxidant properties. Thus, this study aims to investigate the hypoglycemic and protective effect of Olae in the pancreatic of diabetic model rats. The anti-diabetic effect of Olae stems extracts conducted by measuring the blood glucose levels and histological

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... tion of the pancreatic organ in diabetic model rats. All treatment groups with Olae stems extract decreased blood glucose levels compared to the negative control (p<0.05). The dose of 250 mg/kg BW provided higher activity than the 200; 150; and 100 mg/kg BW. Cell numbers of islets showed that Olae stems extract dose of 100; 150; 200; and 250 mg/kg BW increased, compared to normal and negative groups. In conclusion, Olae stems extract provides an anti-diabetic effect with a protective and repairing effect toward islets of Langerhans.