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LGN-dependent orientation of cell divisions in the dermomyotome controls lineage segregation into muscle and dermis
The plane of cell divisions is pivotal for differential fate acquisition. Dermomyotome development provides an excellent system with which to investigate the link between these processes. In the central sheet of the early dermomyotome, single epithelial cells divide with a planar orientation. Here, we report that in the avian embryo, in addition to self-renewing, a subset of progenitors translocates into the myotome where they generate differentiated myocytes. By contrast, in the latedoi:10.1242/dev.065169 pmid:21852400 fatcat:d3zzmcrz4bedfgr223kwai6w3m