Information mining has turned to be increasingly important in the modern digital world. The mining results lead to the essential advances in not only information technology, but general natural science, such as life science, mechanics, numerical analysis, calculation technology, etc. These innovations permitted for the manipulation of biomicrofluidic droplets at micrometer-scale. Through the acquisition of raw data and the multidimensional analysis, numerical modeling can possibly be

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... and the further optimization can be processed. This work was focused on the multi-dimensional analysis based on small samples of the biomicrofludic droplet generation. Then numerical modeling was used to describe the fabrication of microdroplets in complex circumstances. Both linear modeling and nonlinear optimization were performed while the artificial intelligence technology was applied. Although the linear model presented the rough descriptive capacities of microdroplets variation, non-linear optimization improved its descriptive properties. Artificial neural network was established to depict the microfluidic droplets and its accuracy was validated satisfactorily.