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Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis
2015
Frontiers in Neuroscience
The characterization of molecular changes in diseased tissues gives insight into pathophysiological mechanisms and is important for therapeutic development. Genomewide gene expression analysis has proven valuable for identifying biological processes in neurodegenerative diseases using post mortem human brain tissue and numerous datasets are publically available. However, many studies utilize heterogeneous tissue samples consisting of multiple cell types, all of which contribute to global gene
doi:10.3389/fnins.2014.00441
pmid:25620908
pmcid:PMC4288238
fatcat:ho2z6gqt5fgkhjsvhfezfazpe4