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Alternative Angiotensin II Formation in Rat Arteries Occurs Only at Very High Concentrations of Angiotensin I
1999
Hypertension
Contrary to previous reports, recent enzymatic assays showed the predominance of chymase-like activity in rat arteries. We determined the existence and significance of such alternative pathways in rat carotid arteries by measuring contraction of arterial rings in organ baths and blood pressure in conscious rats. Hamster aorta served as a positive control for chymase. Temocapril (30 mol/L) inhibited the contractions to angiotensin (Ang) I (10 Ϫ9 to 10 Ϫ5 mol/L) except at high concentrations of
doi:10.1161/01.hyp.34.3.525
pmid:10489405
fatcat:suuw2rnftba2pdfuj5b3v7wrsa