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A technique for extracting physiological parameters and the required input function simultaneously from PET image measurements: theory and simulation study
1997
IEEE Transactions on Information Technology in Biomedicine
Positron emission tomography (PET) is an important tool for enabling quantification of human brain function. However, quantitative studies using tracer kinetic modeling require the measurement of the tracer time-activity curve in plasma (PTAC) as the model input function. It is widely believed that the insertion of arterial lines and the subsequent collection and processing of the biomedical signal sampled from the arterial blood are not compatible with the practice of clinical PET, as it is
doi:10.1109/4233.681168
pmid:11020827
fatcat:tj2md3huhrfhreuv7gc4q7nili