Eosinophilic infiltration (EI) is commonly causedbyparasitic infections, fungal infection, drug allergy, neoplastic disease, hyper eosinophilic, familial inheritance syndrome, inflammation etc. We report a case of 69 yrs oldman presented as upper digestive tract hemorrhage and abdominal distension for 10 days with eosinophilic infiltration involving liver, gastrointestinal tract (GIT) and lungs. For this case, contrast-enhanced CT of liver showed multiple small, oval or round and low

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... nodules with well or fuzzy margins on sequential arterial and venous phase scans. Pulmonary CT showed small to medium sized multiple irregular nodule with surrounding airspace consolidation or ground-glass opacity and interstitial changes.Gastroendoscopyshowed diffuse bulky mucosa in the fundus and body of the stomach with erosion at surface, and an ulcer at gastric body. Eosinophils count was as high as 26.5×10-9/L (0.02-0.52×10-9/L). The finally diagnose was made by bone biopsy.Treatment had been givenoral prednisone and he was followed-up long term with no evidence of recurrence. Core tip Eosinophilic infiltrations (EI) of multiple organs involving liver, gastric and lungs are very rare.Radiological and endoscopic examinations showed multiple nodules of different in various shape or size at liver, lungs and ulcers are seen at GIT. Eosinophils counts and bone marrow biopsy played a key role for final diagnosis of rare disease is EI of multiple organs. In order to gain a detailed understanding of this rare disease, we reviewed the literature and report here on a recent case of multiple organ eosinophilic infiltration disease in our hospital.