Regional brain abnormalities in behavioral variant frontotemporal dementia: a meta-analysis [post]

Aida Kamalian, Tina khodadadifar, Amin Saberi, Maryam Masoudi, Julia Camilleri, Claudia R. Eickhoff, Mojtaba Zarei, Lorenzo Pasquini, Simon Eickhoff, Masoud Tahmasian
2021 unpublished
INTRODUCTION: Numerous studies have reported brain alterations in behavioral variant frontotemporal dementia (bvFTD). However, they pointed to inconsistent findings. METHODS: We used a meta-analytic approach to identify the convergent structural and functional brain abnormalities in bvFTD. Following the best-practice neuroimaging meta-analysis guidelines, we searched PubMed and Embase databases and performed reference tracking. Then, the coordinates of group comparisons between bvFTD and
more » ... s from 73 studies were extracted and tested for convergence using activation likelihood estimation. RESULTS: We identified convergent abnormalities in the anterior cingulate cortices, anterior insula, amygdala, paracingulate, striatum, and hippocampus. Task-based and resting-state functional connectivity pointed to the joint networks that are connected to the obtained consistent regions. Functional decoding analyses suggested associated dysfunction of emotional processing, interoception, reward processing, higher-order cognitive functions, olfactory and gustatory perceptions in bvFTD.DISCUSSION: Our findings highlighted a key role of the salience network and subcortical regions in the pathophysiology of bvFTD.
doi:10.31234/osf.io/w9pt7 fatcat:fkvxpygxgvgyrc32ugzxukzeim