G583 Spare pens in schools: a survey auditing the uptake of the spare pens in school scheme in peterborough

AC Barker, E Wawrzkowicz
2020 Abstracts   unpublished
Aims To determine the effects of vitamin D supplementation on diverse health outcomes in vitamin D-deficient schoolchildren. Methods We performed a phase 3 randomised placebo-controlled clinical trial in Ulaanbaatar, Mongolia, to determine whether weekly oral supplementation with 14,000 IU vitamin D 3 , administered for 3 years, reduced acquisition of tuberculosis infection in 8,851 schoolchildren aged 6 to 13 years (primary outcome). Secondary efficacy outcomes evaluated in all study
more » ... all study participants included incidence of active tuberculosis, acute respiratory infections, atopic diseases and fractures, and growth and muscle strength. Sub-studies evaluated effects of the intervention on bone mineral density, spirometry and pubertal development (n=1,465), physical fitness (n=615) and examination performance (n=2,097). Safety outcomes included mortality and incidence of serious adverse events. Sub-group analyses were conducted for all efficacy outcomes to determine whether the effect of the intervention varied according to baseline 25-hydroxyvitamin D levels. Results Of the 8,851 randomized participants, 95.6% had vitamin D deficiency (25[OH]D <20 ng/mL) at baseline, and 91.7% completed the study. Mean end-study 25(OH)D levels were 29.8 vs. 9.7 ng/mL in children randomized to intervention vs. placebo (p<0.001). Vitamin D supplementation did not influence the risk of QuantiFERON-TB Gold conversion (P=0.42), incident active tuberculosis (P=0.63), incident asthma (P=0.32), incident atopic dermatitis (P=0.39), incident allergic rhinitis (P=0.45), proportion of children experiencing one or more fractures (P=0.65), mean height-for-age z-score (0.84), mean grip strength (P=0.77), mean bone mineral density at the radius (P=0.14), mean Tanner scores for pubertal development (P!0.28), mean forced expiratory volume in 1 second (FEV1, P=0.35), mean forced vital capacity (FVC, P=0.95), mean maximal oxygen consumption during a 20 metre shuttle run (VO2max, P=0.22) or mean end-of-year mathematics exam scores (P=0.57). Effects of the intervention did not differ according to baseline 25-hydroxyvitamin D levels (<10 ng/mL vs. !10 ng/mL) for any efficacy outcome studied. Neither mortality nor incidence of serious adverse events differed between study arms. Conclusions A weekly oral dose of 14,000 IU vitamin D 3 , administered for 3 years, was safe and effective in elevating 25-hydroxyvitamin D levels into the high physiological range in vitamin D-deficient schoolchildren, but it did not impact any efficacy outcome investigated.
doi:10.1136/archdischild-2020-rcpch.500 fatcat:ramoabvklfbmvfmydk4y3ifhdu