Objective: The study aimed to evaluate treatment effectiveness of biologic-DMARDs and their impact on overall disease control and management among rheumatoid arthritis patients being treated on biologic-DMARDs. Methods: The study was performed among RA patients and disease activity score (DAS) were calculated using DAS 28. Descriptive and inferential statistics were used to obtained the results. Descriptive and inferential statistics were applied using the Statistical Package for Social

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... (SPSS) version 24.0. A p-value < 0.05 was considered statistically significant. Results: Different demographic characteristics were studied from the selected cohort of the RA patients. Around 89 of the studied patients were males and 64 were females. More than half of the patients were 60 years or above. Around 50% of the patients were diagnosed with RA five years or earlier. Among the studied RA patients, a significant therapy response was obtained which resulted in overall improvement in disease outcomes and showed treatment effectiveness among them. Conclusion: From the obtained results, it was concluded that all of the studied RA patients received optimum medication therapy with biologic-DMARDs and achieved significant therapy response which resulted in overall improvement in disease outcomes.