Effect of Naloxone on the Anorexic Action by Glucagon-Like Peptide-1(7-36) in the Neonatal Chick

Takashi BUNGO, Masataka SHIMOJO, Yasuhisa MASUDA, Noboru SAITO, Kunio SUGAHARA, Shin HASEGAWA, Mitsuhiro FURUSE
1999 Japanese poultry science  
It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether the endogenous opioid system contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of GLP-1 inhibited food intake over 2hr. However, the intraperitoneal injection of non-selective opiate antagonist, naloxone, did not
more » ... e the effect of intracerebroventricular administration of chicken GLP-1 (7-36) on feeding behavior. It is suggested that the anorexic effect of GLP-1 may not interact with endogenous opioids in the neonatal chick. (Jpn. Poult. Sci., 36: 109-115, 1999)
doi:10.2141/jpsa.36.109 fatcat:essdxwoquresvmnq5z6unhg2ay