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Immuno Expression of PAKs in Actinic Cheilitis and in Lip Squamous Cell Carcinoma
Journal of Cytology & Histology
Lip squamous cell carcinoma (LSCC) may develop from a potentially malignant disorder known as Actinic cheilitis (AC). The p21-activated kinases (PAKs) are possible targets for cancer therapeutics. The LSSC and AC samples were analyzed by immunohistochemistry in order to detects endogenous levels PAKs group I (PAK1 and PAK2) and group II (PAK4, PAK5 and PAK6) only when they were in phosphorylated form (active). Keratinocytes of the basals stratum showed intense staining for phosphoPAKs 1/2,doi:10.4172/2157-7099.1000330 fatcat:mttbggrs4rg3nhq7m44qu3wyum