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Genomes frequently evolve by reversals (i, j) that transform a gene order 1 . . . i iϩ1 . . . jϪ1 j . . . n into 1 . . . i jϪ1 . . . iϩ1 j . . . n . Reversal distance between permutations and is the minimum number of reversals to transform into . Analysis of genome rearrangements in molecular biology started in the late 1930's, when Dobzhansky and Sturtevant published a milestone paper presenting a rearrangement scenario with 17 inversions between the species of Drosophila. Analysis of genomesdoi:10.1145/225058.225112 dblp:conf/stoc/HannenhalliP95 fatcat:jtirldcpafh2thhfgxqw7igrs4