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Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E
2015
Neurobiology of Aging
Genetic polymorphisms of Catechol-O-methyltransferase (COMT) and Brain-derived neurotrophic factor (BDNF) have shown promising but inconsistent linkages with executive function (EF) in normal aging. We tested (a) independent contributions of COMT and BDNF risk, (b) potential magnification by risk-related interactions or additive effects with age, and (c) effect modification through stratification by Apolipoprotein E (APOE; risk (ε4+)). Multiple linear regression models were applied with
doi:10.1016/j.neurobiolaging.2014.06.020
pmid:25107496
pmcid:PMC4268316
fatcat:5hfm5vla7vagdc4kbmlfnnxjhy