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Folic acid facilitates in vitro maturation of mouse and Xenopus laevis oocytes
British Journal of Nutrition
The water-soluble B vitamins, folate and folic acid, play an important role in reproductive health, but little is known about the effects of folic acid on infertility. The present study tested the hypothesis that folic acid affects oocyte maturation, a possible cause of female infertility. We have studied the in vitro maturation of mouse and Xenopus oocytes. Hypoxanthine (Hx) was used as an inhibitor of mouse oocyte maturation to mimic in vivo conditions by maintaining high levels ofdoi:10.1017/s0007114512003248 pmid:22932126 fatcat:4dgimae7gnhmfayzflijcsco2y