Agent-Based Modeling in Systems Pharmacology

J Cosgrove, J Butler, K Alden, M Read, V Kumar, L Cucurull-Sanchez, J Timmis, M Coles
2015 CPT: Pharmacometrics & Systems Pharmacology  
Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent-based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM-specific strengths have yielded success in the area of preclinical mechanistic modeling.
doi:10.1002/psp4.12018 pmid:26783498 pmcid:PMC4716580 fatcat:kf7lhaq7hbcb3li5queac5yjam