Transcription Regulation and Candidate Diagnostic Markers of Esophageal Cancer

Magbubah Essack, B Vladimir, Bajic
2009 unpublished
Transcription regulation and candidate diagnostic markers of esophageal cancer PhD thesis, South African National Bioinformatics Institute, Faculty of Natural Sciences, University of the Western Cape Esophageal cancer (EC) ranks among the ten most frequent cancers worldwide. Mortality rates associated with EC are very similar to the incidence rates due to the relatively late stage of diagnosis and the poor efficacy of treatment. The aim of this study was to enhance our insights of putative
more » ... criptional circuitry of EC genes, thereby potentially positively impacting our knowledge of therapeutic targets, providing indications as to more appropriate lines of treatment, and additionally allowing for the determination of putative candidate diagnostic markers for the early stage detection of EC. This thesis reports on the development of a novel comprehensive database (Dragon Database of Genes Implicated in Esophageal Cancer, DDEC) as an integrated knowledge database aimed at representing a gateway to esophageal cancer related data. More importantly, it illustrates how the biocurated genes in the database may represent a reliable starting point for divulging transcriptional regulation, diagnostic markers and the biology related to esophageal cancer. Database for exploration of functional context of genes implicated in ovarian cancer, ucleic Acids Res. 37, D820-D823.