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We devised a new combined therapy of CO2 LASER surgery and low-dose macrolide chemotherapy for chronic sinusitis. The effectiveness of this therapy was investigated in patients with chronic sinusitis and bilateral nasal polyps. Sixteen adult patients were first treated with 150 mg of roxithromycin (RXM) per day for more than 3 months, and if nasal symptoms failed to improve further, LASER surgery was performed. Under local anesthesia, nasal polyps were resected and vaporized with 6-8 W CO2LASERdoi:10.5631/jibirin.87.1671 fatcat:sylrbsr36nbuzfdwa3oz45jigu