Aim: to evaluate the efficacy of endoscopic versus microscopic removal of pituitary noninvasive adenoma. Materials and methods: The present prospective comparative was conducted in the Department of Neurosurgery, SKMCH, Muzaffarpur, Bihar, India among 40 patients diagnosed of noninvasive pituitary Adenoma. Group I (n=22); underwent endoscopic transsphenoidal surgery. Group II (n=18): underwent microscopic transsphenoidal surgery. Results: A total of 40 patients with pituitary noninvasive

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... were operated transsphenoidally. Endonasal endoscopic transsphenoidal surgery (group I) was carried out among 22 patients and 18 patients were operated by microscopic transsphenoidal surgery (group II). In group I, complete tumor excision was achieved in 14 (63.6%) patients, and in group II, it was achieved in 10 (55.6%) patients. Conclusion: Both techniques are valid for the treatment of pituitary noninvasive adenomas. However, endoscopy proves to be superior for resection followed by less post-operative complication in comparison to microscopic technique. Keywords: endoscopy, microscopy, pituitary adenoma