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Role of TRPV1 in colonic mucin production and gut microbiota profile
PURPOSE: This study focuses on exploring the role of sensory cation channel Transient Receptor Potential channel subfamily Vanilloid 1 (TRPV1) in gut health, specifically mucus secretion and microflora profile in gut. METHODS AND RESULTS: We employed resiniferatoxin (ultrapotent TRPV1 agonist) induced chemo-denervation model in rats and studied the effects of TRPV1 ablation on gut mucus secretion patterns. Histological and transcriptional analysis showed substantial decrease in mucus productiondoi:10.1101/2020.04.17.046011 fatcat:nppzyyyocveurkp2apszgncffi