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Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study
2011
PLoS Computational Biology
Stochastic expression of genes produces heterogeneity in clonal populations of bacteria under identical conditions. We analyze and compare the behavior of the inducible lac genetic switch using well-stirred and spatially resolved simulations for Escherichia coli cells modeled under fast and slow-growth conditions. Our new kinetic model describing the switching of the lac operon from one phenotype to the other incorporates parameters obtained from recently published in vivo singlemolecule
doi:10.1371/journal.pcbi.1002010
pmid:21423716
pmcid:PMC3053318
fatcat:zyiwxi4vlbdolefsgrvormgr2m