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The α2C-adrenoceptor deletion322–325 variant and cold-induced vasoconstriction
2009
Clinical Autonomic Research
Objectives-Cold-induced vasoconstriction is mediated in part by selective enhancement of local α 2C -adrenoceptor (α 2C -AR) activity. A common insertion-deletion variant in the α 2C -AR gene (ADRA2C del322-325) results in an approximately 85% reduction of agonist-mediated function in vitro. We tested the hypothesis that individuals with the ADRA2C del322-325 variant have attenuated vasoconstriction in response to cold. Methods-Cutaneous digital blood flow (flux) was measured by laser Doppler
doi:10.1007/s10286-009-0014-5
pmid:19444546
pmcid:PMC2739683
fatcat:b5ggj56ld5chfmmx34atmxq3pi