International Journal of Medical Science and Education Original research Article COMPARATIVE ANALYSIS BETWEEN BONE MARROW ASPIRATION CYTOLOGY AND BONE MARROW BIOPSY EXAMINATION IN DIAGNOSIS OF LEUKEMIC PATIENTS

Shubhnita Garg, Mohammed Khushnood
Int.j.med.sci.educ   unpublished
Objective-bone marrow aspiration is main stay in diagnosis of leukemia. Though it is used from long time, sensitivity, diagnostic accuracy is yet not proven. So the objective of our study to find out diagnostic accuracy ,sensitivity ,specificity of bone marrow aspirate (BMA) cytology in diagnosis of leukemia and comparative diagnostic analysis of trephine biopsy with bone marrow aspirate cytology. Material And Method: In our study 30 Patients with suspected diagnosis of leukemia were included.
more » ... mia were included. Data was collected prospectively between Jan2015-Jan2016. The cytology smears were stained using appropriate stains. Bone marrow aspirate diagnosis and histo-pathological results of were compared and concordance was assessed. Result: In the present study we included 30 cases of leukemia in which BMA and bone marrow biopsy (BMB) was done, Out of which 19 cases were of chronic leukemia , 5 case were Acute leukemia, with mean age of 29. Biopsy confirmation of the diagnosis was available in all the cases. Overall diagnostic sensitivity of BMA was 93.3 % for detecting malignancy. There were 02 false negative case were also diagnosed. Cyto-pathological Concordance was high in lymphocytic leukemia. Conclusion: Bone marrow aspiration is a safe and relatively non invasive procedure for diagnosis and evaluation of leukemia.
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