Many questions about the dependence of age-appropriate pathological changes of the skin on background malassezia destruction require clarifi cation and further advance. Aim. In 90 patients with involutive changes in facial skin, including 60 patients with malasseziasis, determination of the state of the epidermis was carried out using electron microscopy. Methods and results. It was found that in 33-40 years old patients leading violation of facial skin is hyperkeratosis. In the age group of

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... 50 years epidermal spongiosis and lymphocytic infi ltration of the epidermis are in the foreground. In patients aged 51-57 years damage of proliferation and differentiation of keratinocytes predominates. Conclusion. This shows the dependence of epidermis pathological changes during malasseziasis on age.