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Study on the effects of parecoxib on hypothalamus orexin neuron of cerebral infarction rats
OBJECTIVE: To explore the effect of parecoxib on cerebral infarction in rats and the regulatory mechanism on hypothalamus orexin neurons (orexin) and protein expression. MATERIALS AND METHODS: 60 SD male rats were randomly divided into sham operation group, model group and treatment group (20 rats in each group). Cerebral infarction model was established by modified Longa method. Rats in the treatment group were given pare-coxib (2.5 mg kg-1) in tail by intravenous injection , while both thefatcat:4bw3s4hc2narfgbj36pd5i367u