Diagnostic Value of Non-Viral Laboratory Markers of Active Epstein – Barr Virus Infection for the Patients with SLE
Ukraïnsʹkij žurnal medicini bìologìï ta sportu
The issue of Epstein-Barr virus is the object of research worldwide. It takes an important place in the structure of inflectional diseases. According to the data by World Health Organization, around 90.00-100.00 % of adults are infected with this virus. One of the most important aspects is the study of the virus among the patients with autoimmune diseases including Systemic Lupus Erythematosus since the primary infection with the virus may cause the aggravation of disease or its reactivation
... its reactivation may influence on the course of and the symptoms of Systemic Lupus Erythematosus which in its turn may complicate the diagnostics and the disease treatment. Diagnostic value of available non-viral hematological tests has not been enough researched yet. Material and methods. We have randomly chosen 120 patients by the criterion of Systemic Lupus Erythematosus. Apart from usual tests, the patients were tested for Epstein-Barr virus infections by the way of IgM and IgG antibodies spotting in the blood serum. Results and discussion. According to the results of general blood test of the patients with Systemic Lupus Erythematosus and active Epstein-Barr virus infection we discovered the reliable connection between the markers, namely: anemia, lymphopenia, monocytosis and accelerated ESR and also the evidence of active Epstein-Barr virus infection. We also discovered a reliable connection between the indices, namely: the increase of the content of creatinine, hyperalaninaminotransferasemia and the increase of hyperaspartataminotransferasemia and the increase of the caption of antistreptolisine О (ASLO), and the evidence of active Epstein-Barr virus infection. Analyzing the changes in proteinogram of the patients with Systemic Lupus Erythematosus, we detected a reliable connection between the markers, namely: the increase of the content of α 1 -globulins, the decrease of the content of γ-globulins, and the evidence of Epstein-Barr virus infection. The results of the analysis of the content of circulating immune complexes allowed us to claim that the increase of the caption of average circulating immune complexes are more frequently detected in the pa-tients with active Epstein-Barr virus infection. The obtained results highlighted a reliable connection between the indices, namely: the increase of the caption ANA and the decrease of index of general complement and the evidence of active Epstein-Barr virus infection. Conclusion. The results of the detection of diagnostic value of the constellations of non-viral laboratory markers of active Epstein-Barr virus infections in the patients with Systemic Lupus Erythematosus did not let us detect peculiar constellations by the sensitivity, specificity and accuracy among them. The evidence of active Epstein-Barr virus infection from the complex of non-viral laboratory markers in the patients with Systemic Lupus Erythematosus is proved by the evidence of hypo α 1-globulinemia, or hyperalaninaminotransferasemia, or the increase of the caption of antinuclear antibodies, or the decrease of the indices of general complement, or monocytosis, or the decrease of the content of creatinine, or anemia, or increase ESR, or the decrease of the caption of average circulating immunological complexes, or hypergamaglobulinemia, or hyperaspartataminotransferasemia, or lymphopenia, which may be used in diagnostic algorithm. We did not find particular constellation according to the sensitivity, specificity and accuracy among non-viral laboratory markers of active Epstein-Barr virus infection in the patients with Systemic Lupus Erythematosus.