Complexes of Zn(II) with mixed tryptanthrin derivative and curcumin chelating ligands as a new promising anticancer agents

Zhen-Feng Wang, Qun-Xue Nong, Hua-Lian Yu, Qi-Pin Qin, Feng-Hua Pan, Mingxiong Tan, Hong Liang, Shuhua Zhang
2022 Dalton Transactions  
In this study, two novel curcumin (H-Cur)–tryptanthrin metal compounds—[Zn(TA)Cl2], i.e., Zn(TA), and [Zn(TA)(Cur)]Cl, i.e., Zn(TAC)—were synthesized and investigated using 5-(bis-pyridin-2-ylmethyl-amino)-pentanoic acid (6,12-dioxo-6,12-dihydro-indolo[2,1-b]quinazolin-8-yl)-amide (TA) and H-Cur as the targeting and high-activity...
doi:10.1039/d1dt04095b pmid:35274641 fatcat:ajprsbg3mbc5zaklfjwbcdjfnq